Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context.

00:53 Doxycycline and the risk of developing schizophrenia
04:03 Emulated target trials versus randomized control trials
06:43 Methods of action
09:24 Dosage and exposure levels for doxycycline
10:15 Immediate clinical applications
10:56 Limitations of the study
11:33 Future research
12:43 Kalin interview
13:00 Lång et al.
19:43 Zhao et al.
25:20 Metrik et al.

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February 2026: Doxycycline Use in Adolescent Psychiatric Patients and Risk of Schizophrenia: An Emulated Target Trial

American Journal of Psychiatry Audio