A conversation with OpenEvidence founder Zachary Zeigler

OpenEvidence, an AI clinical decision support tool, aims to provide physicians with evidence-based answers to medical questions. Zachary Zeigler, co-founder, details how OpenEvidence helps doctors navigate the overwhelming amount of published medical papers to find relevant information for patient care. He shares the company's early struggles and pivots, emphasizing the importance of focusing on solving the core problem and iterating rapidly based on user feedback. A key turning point was expanding the tool's scope beyond clinical trials to include meta-reviews and medical guidelines, increasing its utility for a wider range of clinical questions. Zeigler also highlights the significance of building trust with physicians through bottom-up, peer-driven adoption, rather than top-down mandates.