Unveiling the Molecule That Supercharges Your Mitochondria, Turns Back the Clock on Aging, and Battles Sleep Deprivation, With Dr. Anurag Singh from Timeline Nutrition.

This episode explores Urolithin A, a metabolite produced by gut bacteria from foods like pomegranates and walnuts, and its impact on mitochondrial health and longevity. Against the backdrop of the observation that many people don't produce sufficient Urolithin A due to diet and microbiome composition, the discussion pivots to the benefits of supplementation. More significantly, the interview delves into the mechanistic action of Urolithin A, highlighting its role in mitophagy—the process of removing damaged mitochondria—leading to improved mitochondrial quality and quantity. For instance, studies show that Urolithin A supplementation improves muscle performance, recovery, and even grip strength in older adults, mimicking the effects of regular exercise. The conversation also touches upon the safety and efficacy of different Urolithin A delivery methods (soft gels, powders, etc.), optimal dosage and timing for various goals (e.g., workout recovery, sleep improvement), and potential synergistic effects when combined with other supplements like NAD or CoQ10. Finally, future research directions are discussed, including investigations into Urolithin A's effects on the immune system, cognitive health, and its potential interaction with nootropics. This means for the listener is a deeper understanding of Urolithin A's potential as a supplement for enhancing mitochondrial function and overall health.