#381 ‒ Alzheimer's disease in women: how hormonal transitions impact the female brain, the role of HRT, genetics, and lifestyle on risk, and emerging diagnostics and therapies | Lisa Mosconi, Ph.D. | The Peter Attia Drive

This podcast explores the disproportionate impact of Alzheimer's disease on women, challenging the assumption that increased longevity is the sole factor. Neuroscientist Lisa Mosconi discusses her personal connection to the topic and her research on how menopause and hormonal transitions shape brain aging and Alzheimer's risk in women. The conversation covers advanced imaging techniques that reveal preclinical Alzheimer's, the role of estrogen brain receptors, and the impact of ApoE4 and other genetic risks, which seem to affect women more. Mosconi introduces the CARE Initiative, a global effort to reduce women's Alzheimer's risk by 2050, and evidence-based strategies for supporting brain health during midlife transitions, including lifestyle adjustments, sleep optimization, and the potential role of medications.

Outlines

Part 1: Introduction, Personal Background

Part 2: Alzheimer’s Pathology, Gender Disparity

Part 3: Estrogen Receptors, Hormone Therapy

Part 4: Research Initiatives, Data Challenges

Part 5: Clinical Applications, Future Outlook

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#381 ‒ Alzheimer's disease in women: how hormonal transitions impact the female brain, the role of HRT, genetics, and lifestyle on risk, and emerging diagnostics and therapies | Lisa Mosconi, Ph.D.

The Peter Attia Drive

Part 1: Introduction, Personal Background

Introduction to Women's Brain Health and Alzheimer's with Lisa Mosconi

Lisa Mosconi's Personal Journey into Alzheimer's Research and Dementia Overview

Part 2: Alzheimer’s Pathology, Gender Disparity

Differentiating Alzheimer's from Other Forms of Dementia

Alzheimer's Disproportionately Affects Women: Challenging the Longevity Explanation

Menopause, Estrogen Loss, and Alzheimer's Risk in Women

Part 3: Estrogen Receptors, Hormone Therapy

Measuring Estrogen Receptors in the Brain and Challenging Preclinical Models

The Window of Opportunity for Hormone Therapy and the Women's Health Initiative

The Importance of Brain Estrogen Levels and the Role of Transporters

Part 4: Research Initiatives, Data Challenges

CARE Initiative: Cutting Alzheimer's Risk Through Endocrinology

Hormone Replacement Therapy and Alzheimer's Risk: Addressing the Healthy User Bias

Selective Estrogen Receptor Modulators (SERMs) and the Fear of Estrogen

The Women's Health Initiative's Lingering Impact and the Need for Better Data

Part 5: Clinical Applications, Future Outlook

Reproductive History as a Stress Test and the Importance of Hormonal History

GLP-1 Agonists and Hormone Replacement Therapy: What Should Women Do Differently?

Consistency in Lifestyle Choices and Optimism for Future Dementia Treatments

#381 ‒ Alzheimer's disease in women: how hormonal transitions impact the female brain, the role of HRT, genetics, and lifestyle on risk, and emerging diagnostics and therapies | Lisa Mosconi, Ph.D.

The Peter Attia Drive

Part 1: Introduction, Personal Background

00:09Introduction to Women's Brain Health and Alzheimer's with Lisa Mosconi

Introduction to Women's Brain Health and Alzheimer's with Lisa Mosconi

03:57Lisa Mosconi's Personal Journey into Alzheimer's Research and Dementia Overview

Lisa Mosconi's Personal Journey into Alzheimer's Research and Dementia Overview

Part 2: Alzheimer’s Pathology, Gender Disparity

11:26Differentiating Alzheimer's from Other Forms of Dementia

Differentiating Alzheimer's from Other Forms of Dementia

16:35Alzheimer's Disproportionately Affects Women: Challenging the Longevity Explanation

Alzheimer's Disproportionately Affects Women: Challenging the Longevity Explanation

25:34Menopause, Estrogen Loss, and Alzheimer's Risk in Women

Menopause, Estrogen Loss, and Alzheimer's Risk in Women

Part 3: Estrogen Receptors, Hormone Therapy

35:59Measuring Estrogen Receptors in the Brain and Challenging Preclinical Models

Measuring Estrogen Receptors in the Brain and Challenging Preclinical Models

47:11The Window of Opportunity for Hormone Therapy and the Women's Health Initiative

The Window of Opportunity for Hormone Therapy and the Women's Health Initiative

57:34The Importance of Brain Estrogen Levels and the Role of Transporters

The Importance of Brain Estrogen Levels and the Role of Transporters

Part 4: Research Initiatives, Data Challenges

1:07:37CARE Initiative: Cutting Alzheimer's Risk Through Endocrinology

CARE Initiative: Cutting Alzheimer's Risk Through Endocrinology

1:17:34Hormone Replacement Therapy and Alzheimer's Risk: Addressing the Healthy User Bias

Hormone Replacement Therapy and Alzheimer's Risk: Addressing the Healthy User Bias

1:25:02Selective Estrogen Receptor Modulators (SERMs) and the Fear of Estrogen

Selective Estrogen Receptor Modulators (SERMs) and the Fear of Estrogen

1:33:14The Women's Health Initiative's Lingering Impact and the Need for Better Data

The Women's Health Initiative's Lingering Impact and the Need for Better Data

Part 5: Clinical Applications, Future Outlook

1:42:08Reproductive History as a Stress Test and the Importance of Hormonal History

Reproductive History as a Stress Test and the Importance of Hormonal History

1:49:11GLP-1 Agonists and Hormone Replacement Therapy: What Should Women Do Differently?

GLP-1 Agonists and Hormone Replacement Therapy: What Should Women Do Differently?

1:57:33Consistency in Lifestyle Choices and Optimism for Future Dementia Treatments

Consistency in Lifestyle Choices and Optimism for Future Dementia Treatments