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Nicotine may not be the addictive villain it's made out to be. When separated from cigarette smoke, it shows surprising anti-inflammatory and neurological potential.

Summary:

In this Metabolic Classroom mini lecture, Dr. Ben Bikman revisits the molecule nicotine—not as an endorsement to use it, but to explore its distinct effects when separated from harmful compounds in cigarettes.

Contrary to popular belief, nicotine alone is not highly addictive; tobacco additives like pyrazines likely amplify the addiction seen in cigarettes. Dr. Bikman details nicotine’s anti-inflammatory properties, particularly through activation of the alpha-7 nicotinic acetylcholine receptor, which may help conditions like ulcerative colitis, sepsis, and arthritis.

Ben also explores its complex effects on metabolism—such as increased thermogenesis and fat oxidation—while warning of potential insulin resistance with sustained use.

Lastly, he reviews fascinating clinical research suggesting therapeutic potential in conditions like ADHD, autism, Tourette’s syndrome, and even Alzheimer’s, all while emphasizing that nicotine, when separated from cigarette smoke, warrants more open scientific inquiry.

References:

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NOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions.

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Separating Nicotine from Smoking: Myths, Metabolism, and Medicine

The Metabolic Classroom with Dr. Ben Bikman