Shalin Shah is the CEO of Marius Pharmaceuticals and widely known as The Metabolic CEO. He’s a leading voice in metabolic health and hormone therapy innovation, and one of the strongest advocates working to destigmatize testosterone for both men and women.

In this episode, we go deep into what’s really happening with testosterone today — why levels are declining across the population, why this is not just a “male” issue, and why testosterone is foundational to metabolic health, longevity, mental health, bone density, and quality of life. Shalin breaks down complex science in a way that’s practical and empowering, and explains why testosterone deficiency is being massively underdiagnosed and undertreated.

We talk about environmental toxins, sleep disruption, stress, lifestyle, and the long-term consequences of ignoring low testosterone — including cardiovascular disease, diabetes, depression, frailty, and increased all-cause mortality. We also explore the future of hormone therapy, why testing should be standard, and how innovation like oral testosterone could change access and outcomes for millions of people.

This conversation is informative, eye-opening, and honestly a bit of a wake-up call — especially for anyone in midlife who wants to age strong, think clearly, and feel energized again.

What we cover:

Why testosterone levels are declining in men and women
Testosterone as a metabolic health marker, not a lifestyle drug
The role of sleep, stress, toxins, and modern life
Why fatigue, brain fog, depression, and low motivation are often hormonal
The truth about testosterone myths and stigma
Why testing matters — and why baselines should start early
The difference between “normal” and “optimal” hormone levels
Oral vs topical vs injectable testosterone
Why muscle, bone health, and longevity are directly tied to hormones
What’s changing at the FDA — and why this moment matters

Panel: https://www.fda.gov/patients/fda-expert-panels/fda-expert-panel-testosterone-replacement-therapy-men-12102025?

Comments: https://www.regulations.gov/document/FDA-2025-N-6743-0001/comment

www.kyzatrex.com

https://www.instagram.com/themetabolicceo/

Please remember to rate, review, and follow the show – and share with a friend!

Check out our new Comedy Wellness Podcast: Anything But Mid, cohosted with Whitney Stropp:

https://podcasts.apple.com/us/podcast/anything-but-mid/id1849386215

https://www.youtube.com/@AnythingButMid

Find Amy’s affiliates and discount codes: https://amyedwards.info/affiliatepage

Sky Rock Sedona:

https://www.skyrocksedona.com/

20% Discount Link:

https://www.marriott.com/event-reservations/reservation-link.mi?id=1759866624184&key=CORP&app=resvlink

All links: ⁠⁠⁠amyedwards.info⁠⁠⁠

Instagram: ⁠⁠⁠@realamyedwards⁠⁠⁠

Fight For Her: ⁠⁠⁠fightforher.net⁠⁠⁠

TikTok:⁠⁠⁠ @themagicbabe⁠⁠⁠

YouTube: ⁠⁠⁠YouTube Channel⁠⁠⁠

Podcast: ⁠⁠⁠The Amy Edwards Show Podcast⁠⁠⁠

Free Course:⁠⁠⁠ The Ageless Mindset⁠⁠⁠

Full Course: ⁠⁠⁠The Youthfulness Hack⁠⁠⁠

Work with Amy:⁠⁠⁠ ⁠⁠⁠⁠⁠⁠Book a Call⁠⁠⁠

Let’s get you to your HAPPIEST and most RADIANT! Book a call to apply to work together one-on-one:

⁠https://amyedwards.as.me/15mincall⁠

Amy’s hair by ⁠https://www.thecollectiveatx.com⁠

Podcast editing by https://podcastmagician.com/

Get my FREE course "The Ageless Mindset: The Ultimate Guide to Look Younger and Feel Happier!" HERE: ⁠https://best-you-life.teachable.com/p/the-ageless-mindset-the-ultimate-guide-to-look-younger-feel-happier⁠

Get the full course “The Youthfulness Hack: The Secret System to Reverse Aging Fast and Create a New, Radiant You!” Out now! ⁠https://best-you-life.teachable.com/p/the-youthfulness-hack⁠

255 - Testosterone in 2026: What You Need to Know Now with Shalin Shah, "The Metabolic CEO" and Testosterone Expert

The Amy Edwards Show