How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — Dr. Dom D'Agostino

The podcast explores the benefits, risks, and practical applications of ketosis and ketogenic diets, particularly for mental health, neuroprotection, and managing diseases like Lyme and cancer. Dr. D'Agostino, an expert in ketosis, discusses how ketosis quiets the mind by elevating GABA and lowering glutamate, potentially aiding metabolic psychiatry. He also explains how limiting glucose availability can target the energy systems of glycolytic microbes like Borrelia, while beta-hydroxybutyrate stimulates the adaptive immune response. Tim Ferriss shares his personal experiences using ketosis to combat cognitive symptoms from Lyme disease and notes the importance of metabolic flexibility, mitochondrial function, and personalized approaches to diet. The conversation also covers the nuances of protein intake, the importance of dietary fat, and the potential toxicity of certain exogenous ketones like 1,3-butanediol.