#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment) | The Tim Ferriss Show

This episode explores the practical applications and benefits of ketosis with Dr. Dominic D'Agostino. Tim Ferriss, who has experimented with ketogenic diets since the 90s, shares his experiences using ketosis for mood stabilization and cognitive enhancement, particularly in managing Lyme disease symptoms. D'Agostino details the cognitive benefits of ketosis, such as quieting the mind by elevating GABA levels, and its potential in metabolic psychiatry for conditions like depression and anxiety. The conversation covers strategies for implementing a ketogenic diet, including intermittent fasting and specific food choices, while also addressing potential drawbacks like toxicity from certain ketone supplements and the importance of monitoring individual metabolic responses. They further discuss the role of ketosis in preventing neurodegenerative diseases and optimizing metabolic health through regular monitoring and lifestyle adjustments.

Outlines

Part 1: Introduction, Mental Health, and Disease

Part 2: Metabolic Memory and Practical Implementation

Part 3: Physiology, Digestion, and Exercise

Part 4: Neuroprotection and Long-term Strategy

Part 5: Exogenous Ketones and Toxicity Risks

Part 6: Nutrition, Safety, and Resources

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#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

The Tim Ferriss Show

Part 1: Introduction, Mental Health, and Disease

00:00Ketosis Benefits, Implementation, and Challenges: An Introduction with Dom D'Agostino

Ketosis Benefits, Implementation, and Challenges: An Introduction with Dom D'Agostino

04:14Ketosis Benefits: Quieting the Mind, Elevating GABA, and Metabolic Psychiatry Applications

Ketosis Benefits: Quieting the Mind, Elevating GABA, and Metabolic Psychiatry Applications

07:46Physical Benefits of Ketosis: Weight Loss, Insulin Reduction, and Fat Burning

Physical Benefits of Ketosis: Weight Loss, Insulin Reduction, and Fat Burning

10:18Ketosis and Lyme Disease: Targeting Energy Systems and Augmenting Immune Response

Ketosis and Lyme Disease: Targeting Energy Systems and Augmenting Immune Response

16:11Ketosis and Cancer: Slowing Tumor Growth and Enhancing Standard Care

Ketosis and Cancer: Slowing Tumor Growth and Enhancing Standard Care

Part 2: Metabolic Memory and Practical Implementation

20:49Ketosis for Mood Stabilization, Neuroprotection, and Metabolic Memory

Ketosis for Mood Stabilization, Neuroprotection, and Metabolic Memory

23:59Metabolic Memory, Practical Implementation of Ketosis, and Mackerel-Based Diet

Metabolic Memory, Practical Implementation of Ketosis, and Mackerel-Based Diet

27:20Monitoring Ketosis: Continuous Monitors, Finger Pricks, and Unexpected Low Readings

Monitoring Ketosis: Continuous Monitors, Finger Pricks, and Unexpected Low Readings

35:14High Insulin Sensitivity and Ketone Utilization: Explaining Low Ketone Readings

High Insulin Sensitivity and Ketone Utilization: Explaining Low Ketone Readings

Part 3: Physiology, Digestion, and Exercise

39:31Gluconeogenesis, Protein Intake, and Slowing Amino Acid Absorption

Gluconeogenesis, Protein Intake, and Slowing Amino Acid Absorption

42:55Stomach Size, Mechanoreceptors, and the Sympathetic Nervous System's Impact on Ketosis

Stomach Size, Mechanoreceptors, and the Sympathetic Nervous System's Impact on Ketosis

47:22Timing Walks After Meals: Attenuating Glucose Spikes and Buffering Ketogenesis

Timing Walks After Meals: Attenuating Glucose Spikes and Buffering Ketogenesis

50:55Continuous Monitors, Subjective Feel, and Muscle Mass on Ketosis

Continuous Monitors, Subjective Feel, and Muscle Mass on Ketosis

58:04Rabbit Starvation and Dietary Fat: The Importance of Exogenous Fat in Ketosis

Rabbit Starvation and Dietary Fat: The Importance of Exogenous Fat in Ketosis

1:02:24Dietary Fat Importance: Fueling the Body and Stimulating Beta-Oxidation

Dietary Fat Importance: Fueling the Body and Stimulating Beta-Oxidation

Part 4: Neuroprotection and Long-term Strategy

1:04:17Ketogenic Diet and Neurodegenerative Disease: Improving Cardio-Immunometabolic Biomarkers

Ketogenic Diet and Neurodegenerative Disease: Improving Cardio-Immunometabolic Biomarkers

1:09:36Metabolic Dysfunction, Estrogen Blockers, and the Minimum Effective Dose of Ketosis

Metabolic Dysfunction, Estrogen Blockers, and the Minimum Effective Dose of Ketosis

1:14:22Low-Carb Diets, Metabolic Flexibility, and the Importance of Exercise

Low-Carb Diets, Metabolic Flexibility, and the Importance of Exercise

1:18:01Frequency of Ketosis: One Week Per Month vs. Three Contiguous Weeks

Frequency of Ketosis: One Week Per Month vs. Three Contiguous Weeks

1:23:55Glucose Ketone Index (GKI) and the Challenge of Low Ketone Readouts

Glucose Ketone Index (GKI) and the Challenge of Low Ketone Readouts

1:27:30Expanding the GKI Range and the Energetic and Vascular Benefits of Ketones

Expanding the GKI Range and the Energetic and Vascular Benefits of Ketones

1:31:39Trusting the Process and Measuring Physical and Cognitive Metrics

Trusting the Process and Measuring Physical and Cognitive Metrics

Part 5: Exogenous Ketones and Toxicity Risks

1:37:30Exogenous Ketones: Palatability, Tolerability, Pharmacokinetics, and Toxicity

Exogenous Ketones: Palatability, Tolerability, Pharmacokinetics, and Toxicity

1:39:20Toxicity of 1,3-Butanediol: Liver Inflammation and ATP Depletion

Toxicity of 1,3-Butanediol: Liver Inflammation and ATP Depletion

1:42:28Human vs. Animal Models: Transaminases and the Importance of Liver Health

Human vs. Animal Models: Transaminases and the Importance of Liver Health

1:46:20Trending Away from 1,3-Butanediol: Free Acids, Triesters, and Ketone Salts

Trending Away from 1,3-Butanediol: Free Acids, Triesters, and Ketone Salts

1:51:16MCT Oil and Ketone Monoester: Benefits, Risks, and Insulin Spikes

MCT Oil and Ketone Monoester: Benefits, Risks, and Insulin Spikes

1:55:02Ketogenic Breakfast vs. Intermittent Fasting and 1,3-Butanediol Dependence

Ketogenic Breakfast vs. Intermittent Fasting and 1,3-Butanediol Dependence

1:58:281,3-Butanediol: Narcotic Effects, Alcohol Replacement, and Dangers for Older People

1,3-Butanediol: Narcotic Effects, Alcohol Replacement, and Dangers for Older People

2:03:12Richard Veach and the Conception of Ketone Esters

Richard Veach and the Conception of Ketone Esters

Part 6: Nutrition, Safety, and Resources

2:05:08Favorite Sources of Fiber: Broccoli, Wild Blueberries, and Apples

Favorite Sources of Fiber: Broccoli, Wild Blueberries, and Apples

2:07:31Carbohydrate Tolerance and the Benefits of Adding Carbs Back into the Diet

Carbohydrate Tolerance and the Benefits of Adding Carbs Back into the Diet

2:11:00Cautionary Tale: Contaminated Gummies and the Importance of Product Safety

Cautionary Tale: Contaminated Gummies and the Importance of Product Safety

2:13:07Resources and Closing Remarks: Ketonutrition.org, Metabolic Link Podcast, and More

Resources and Closing Remarks: Ketonutrition.org, Metabolic Link Podcast, and More