The Gut-Muscle-Immune Axis: How Mitophagy Rewires Your Body for Longevity

The podcast explores the intricate relationship between the immune system and skeletal muscle health, particularly as it relates to aging. Dr. Anurag Singh, an immunologist, joins Dr. Lyon to discuss how the immune system, often overlooked in aging research, plays a crucial role in overall healthspan. They delve into the decline of youthful immune cells and the dysregulation and exhaustion of immune function with age, also touching on the thymus's role. The conversation highlights the potential of interventions like Urolithin A, a postbiotic, to improve mitochondrial function within immune cells, shifting their fuel source from glucose to fatty acids. The discussion also covers the importance of exercise and diet in maintaining a healthy immune system, as well as future research directions, including the impact of these interventions on cancer and brain health.