This podcast episode explores the intricacies of the human brain and its role in intelligence. The conversation with Jeff Hawkins, founder of the Redwood Center for Theoretical Neuroscience and Numenta, highlights the importance of understanding the brain as a fast route to achieving machine intelligence. Jeff emphasizes the significance of studying the neocortex, the key area associated with intelligence, and the need for theoretical frameworks to integrate empirical data. The episode also delves into the concept of the Thousand Brain Theory of Intelligence, which explains how the neocortex processes information by assigning everything to reference frames. The discussion touches on the role of attention, inhibitory neurons, and sparse representations in cognitive processes. The speakers also discuss the importance of neuroscience and synaptogenesis in AI learning, the mechanisms of learning and memory in neural networks, and the challenges of building intelligent machines. The concept of consciousness and the fear of death are also explored, with the speakers acknowledging that understanding consciousness is not necessary for building intelligent machines but still an intriguing topic worth exploring. The episode concludes by discussing concerns about existential threats posed by intelligence systems and the importance of preserving knowledge as humanity's legacy.