This podcast episode explores the importance of eating less often for longevity and overall health. It discusses the role of sirtuins and NAD boosters in extending lifespan, the significance of fasting and drugs that mimic fasting, and the benefits of fasting in improving blood pressure, BMI, and weight circumference. The episode also delves into various diets related to fasting and time-restricted feeding, the negative effects of glucose and high protein on longevity, the importance of autophagy and adopting a plant-based diet, the impact of specific diets on mortality rates, the concept of xenohormesis and stressed foods, and the benefits of being lean as an older person. The conversation emphasizes the need for informed decisions based on available research and individualized approaches.