This podcast episode explores the regulation of molecules in our food supply, specifically focusing on generally recognized as safe (GRAS) molecules that are not regulated by the FDA. It introduces the concept of NAD boosters and their potential benefits in longevity research. The conversation then delves into the significance of NAD boosters and sirtuins in the human body, discussing their role in energy production and overall survival. The potential benefits and effectiveness of NMN and NR in extending lifespan, improving health, and treating mitochondrial disorders are discussed. The podcast also covers the potential uses of NMN and NR in treating addiction, depression, and hangovers, as well as the bioavailability of these NAD boosters. The effects of resveratrol and senolytics on health and longevity are examined, along with the potential benefits of metformin as an AMPK activator. The conversation concludes with a discussion on various supplements and drugs for longevity, highlighting the importance of personalized healthcare advice and the need for further research in the field.