This podcast episode explores the crucial role of the blood-brain barrier (BBB) in cognitive health and dementia. The BBB, a protective layer surrounding the brain, prevents harmful substances from entering. However, as we age and in diseases like Alzheimer's, the BBB can become damaged, leading to leaks and inflammation. The episode emphasizes the importance of maintaining a healthy BBB through lifestyle factors, such as exercise, managing blood pressure, and supporting the vascular system. It also discusses promising research into targeting BBB dysfunction as a potential treatment for dementia.