Matt examines the critical link between sleep quality and Alzheimer’s pathology. He details the brain's "night shift" - the glymphatic system - which actively flushes out toxins like amyloid beta during deep sleep. Listeners learn how even a single night of deprivation can spike harmful tau levels by 50%, effectively accelerating brain aging.

The discussion pivots to dual orexin receptor antagonists (DORAs), a drug class that quiets wakefulness rather than forcing sedation. Matt highlights research from Dr. Brendan Lucey and Dr. David Holtzman showing these agents may lower toxic proteins and preserve the hippocampus. Despite this therapeutic promise, he emphasizes that natural sleep remains the ultimate gold standard for neuroprotection.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

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As always, if you have thoughts or feedback you’d like to share, please reach out to Matt:

Matt: Instagram @drmattwalker, X @sleepdiplomat,

YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg

#118 - A Sleep Medication to Lower the Risk of Alzheimer's

The Matt Walker Podcast