Molecular biologist Judith Frydman studies the nuances of protein folding and how defects in the process lead to neurodegenerative diseases. Her team studies protein folding in human cells and in model organisms, like yeast and worms, to understand the molecular events that precipitate harmful protein defects in humans. In one example, Frydman’s team explored how aging affects the creation and the quality of proteins in the brain, leading to cognitive problems. She is now looking to develop therapies – someday perhaps leading to cures – to debilitating diseases such as Alzheimer’s, Parkinson’s, Huntington’s, ALS, and others. The power of science gives her true hope in these important pursuits, Frydman tells host Russ Altman in this episode of Stanford Engineering’s The Future of Everything podcast.

Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu.

Episode Reference Links:

Stanford Profile: Judith Frydman

Connect With Us:

Episode Transcripts >>> The Future of Everything Website
Connect with Russ >>> Threads / Bluesky / Mastodon
Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook

Chapters:

(00:00:00) Introduction

Russ Altman introduces guest Judith Frydman, a professor of biology and genetics at Stanford University.

(00:04:00) Linking Protein Folding to Aging

How aging disrupts protein-folding machinery across many organisms.

(00:07:16) Universal Aging Patterns

The similar age-related protein-folding defects found across organisms

(00:09:27) Studying Killifish Ageing

Research on the African killifish as a rapid-aging model organism.

(00:13:05) Ribosome Function Declines

How aging causes ribosomes to stall and collide, creating faulty proteins.

(00:15:31) Aging Across Species

The potential factors causing alternate aging rates in different species.

(20:11) What Fails Inside Aging Cells

The cellular components that are leading to bad protein creation.

(00:24:04) Therapeutic Approaches

Potential interventions to combat cellular and neurological degeneration.

(00:25:12) Gene vs. Small-Molecule Treatments

How some interventions may be better suited for certain diseases.

(00:27:47) Ribosome Drug Potential

Why ribosomes and translation factors are viable drug targets.

(00:28:56) Next Steps in Aging Research

Using human skin fibroblasts to study human aging mechanisms.

(00:31:46) Future In a Minute

Rapid-fire Q&A: scientific progress, young researchers, and archeology.

(00:33:54) Conclusion

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads / Bluesky / Mastodon

Connect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The future of neurodegeneration

The Future of Everything