Immune 98: T cells on the brain

In episode 98 of Immune, Vincent Racaniello is joined by Cindy Leifer, Brianne Barker, and Steph Langel to discuss the body's defense against disease. The hosts begin by discussing the use of Celsius and announce the upcoming Immune 100 event in December. Vincent presents a snippet on antibody cross-reactivity to influenza H5N1 neuraminidase, focusing on a Cell Host Microbe paper. Steph then discusses a Nature paper on T cells in the brain and their role in regulating behavior, exploring the concept of immune privilege in the central nervous system and the gut-brain axis. The panel discusses the implications of the research, including the potential for vaccine design and understanding neurological disorders.

Outlines

Part 1: Influenza Neuraminidase Antibodies

Part 2: T Cells in the Brain - Introduction and Identification

Part 3: Origin and Trafficking of Brain T Cells

Part 4: Behavioral Impact and Conclusions

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Immune

Part 1: Influenza Neuraminidase Antibodies

Introduction to Immune Episode 98 and Discussion on Temperature Scales

Antibody Cross-Reactivity to Influenza H5N1 Neuraminidase

Structural Analysis and Evolution of Broadly Reactive Neuraminidase Antibodies

Protection Against Influenza Challenge and Transition to T Cells in the Brain

Part 2: T Cells in the Brain - Introduction and Identification

Introduction to T Cells in the Brain and the Concept of Immune Privilege

Identifying T Cells in the Subfornical Organ and Their Transcriptional Differences

Part 3: Origin and Trafficking of Brain T Cells

Investigating the Origin of Brain T Cells: White Adipose Tissue and the Gut-Brain Axis

T Cell Receptor Specificity and the Role of CXCR6 in Brain T Cell Trafficking

Part 4: Behavioral Impact and Conclusions

Behavioral Outcomes and Concluding Remarks on T Cells in the Brain

Immune 98: T cells on the brain

Immune

Part 1: Influenza Neuraminidase Antibodies

00:04Introduction to Immune Episode 98 and Discussion on Temperature Scales

Introduction to Immune Episode 98 and Discussion on Temperature Scales

07:50Antibody Cross-Reactivity to Influenza H5N1 Neuraminidase

Antibody Cross-Reactivity to Influenza H5N1 Neuraminidase

16:10Structural Analysis and Evolution of Broadly Reactive Neuraminidase Antibodies

Structural Analysis and Evolution of Broadly Reactive Neuraminidase Antibodies

27:48Protection Against Influenza Challenge and Transition to T Cells in the Brain

Protection Against Influenza Challenge and Transition to T Cells in the Brain

Part 2: T Cells in the Brain - Introduction and Identification

33:30Introduction to T Cells in the Brain and the Concept of Immune Privilege

Introduction to T Cells in the Brain and the Concept of Immune Privilege

42:03Identifying T Cells in the Subfornical Organ and Their Transcriptional Differences

Identifying T Cells in the Subfornical Organ and Their Transcriptional Differences

Part 3: Origin and Trafficking of Brain T Cells

53:01Investigating the Origin of Brain T Cells: White Adipose Tissue and the Gut-Brain Axis

Investigating the Origin of Brain T Cells: White Adipose Tissue and the Gut-Brain Axis

1:04:14T Cell Receptor Specificity and the Role of CXCR6 in Brain T Cell Trafficking

T Cell Receptor Specificity and the Role of CXCR6 in Brain T Cell Trafficking

Part 4: Behavioral Impact and Conclusions

1:17:57Behavioral Outcomes and Concluding Remarks on T Cells in the Brain

Behavioral Outcomes and Concluding Remarks on T Cells in the Brain