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In this mini-lecture, Ben explores the biochemical and physiological differences between plant and animal proteins—avoiding environmental or ethical debates and focusing strictly on metabolism and human health. He breaks down essential amino acids, emphasizing that animal proteins are "complete" sources, while most plant proteins fall short—particularly in leucine, which is vital for muscle protein synthesis.

Dr. Bikman also discusses digestibility and bioavailability, explaining why animal proteins are more efficiently absorbed than plant sources. He introduces the DIAAS scoring system and details studies showing how much less effective plant proteins are at raising amino acid levels in the blood compared to animal proteins like pork or eggs.

Importantly, the lecture addresses “antinutrients” in plant proteins—like trypsin inhibitors, phytates, and lectins—which impair protein digestion and mineral absorption. These antinutrients are also implicated in autoimmune responses, especially when intestinal permeability is compromised. Dr. Bikman explains how fermentation, soaking, and pressure cooking can help—but not eliminate—these compounds.

The lecture concludes by warning about heavy metal contamination in plant-based protein powders and reminds us that while plant proteins can support health, they require more planning and carry additional nutritional burdens compared to their animal-based counterparts.

Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber or member. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, unlimited access to Dr. Bikman’s Digital Mind, ad-free podcast episodes, show notes and references, and online, live Office Hours access with Ben. It also includes Ben’s Weekly Research Review Podcast, and a searchable archive. Learn more: https://www.benbikman.com

IMPORTANT NOTE: The information presented is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Dr. Bikman is not a clinician—and, he is not your doctor. Always seek the advice of your own qualified health providers with questions you may have regarding medical conditions.

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Plant Protein vs Animal Protein: What the Science Really Says

The Metabolic Classroom with Dr. Ben Bikman