SGLT-2i vs. GLP-1? vs Metformin? How do you balance the cost and coverage of first-line options like metformin, SGLT-2, and GLP-1s? How do you choose between SGLT-2 and GLP-1s for comorbidities like CAD or CKD? And how do you weigh their side effects and practical use?

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🔹 Transcript and Show Notes

Timestamps:

(01:42) | Starting Treatment for Newly Diagnosed Type 2 Diabetes

(08:40) | Balancing Cost, Coverage, and First-Line Therapy Choices

(13:44) | Choosing Therapy for CAD and CKD: The Case for SGLT2 vs. GLP-1

(19:42) | Managing Obesity, Sleep Apnea, and Pain in Diabetes Care

(27:57) | Rethinking Sulfonylureas and Shifting Toward Modern Agents

(29:07) | Choosing Between GLP-1 and SGLT2 Inhibitors for Comorbidities

(35:34) | Weighing Side Effects and Practical Use of GLP-1 and SGLT2 Inhibitors

Tags: CoreIM, Primary Care, Endocrinology, Diabetes Mellitus, Type 2 Diabetes, Type 1 Diabetes, Metformin, GLP-1, SGLT2, Insulin, CGM, A1C, DKA, Medical Education, Clinical Reasoning, Hospital Medicine

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#192 Debate on First-Line Medications for Diabetes

Core IM | Internal Medicine Podcast