Psilocybin, LSD & Marijuana: Ranking Drugs for Longevity (Part 2)

The podcast explores the potential longevity benefits and risks associated with various recreational drugs, including psilocybin, LSD, DMT, and marijuana. It highlights a study suggesting psilocybin may lengthen telomeres and extend lifespan in mice, prompting discussion of a potential psilocybin protocol for humans, while LSD showed similar effects in worms by mimicking caloric restriction. The conversation also tackles marijuana, noting CBD's potential benefits for anxiety and inflammation, but also THC's downsides like increased lung cancer risk from smoking and potential negative impacts on epigenetic aging. The hosts share personal experiences and consider the complex and individualistic effects of these substances.

Outlines

Part 1: Introduction, Personal History

Part 2: Philosophy, Therapy, Risks

Part 3: Psilocybin, LSD, DMT Research

Part 4: Marijuana Analysis

Part 5: Summary, Rankings, Future

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Bryan Johnson Podcast

Part 1: Introduction, Personal History

Psychedelics and Longevity: An Introduction to Shrooms, LSD, DMT, and Marijuana

First Drug Experiences: Marijuana Encounters at Ages 13-15

Psychedelics in Society: Trauma Processing and Freedom of Thought

Part 2: Philosophy, Therapy, Risks

Psychedelics and "Don't Die" Ideology: Cultish Implications and Processing

Exploring Psychedelic Therapy: Death, Ibogaine Risks, and Ketamine

Part 3: Psilocybin, LSD, DMT Research

Psilocybin and Longevity: Mouse Studies and Potential Mechanisms

Psilocybin Protocol Considerations: IRB Approval, Location, and Measurements

Psilocybin's Nuances: Telomere Elongation, Cellular Behavior, and Preliminary Research

Exploring Consciousness: Worms on LSD and the Limitations of Experience

Psychedelics: Contraindications, Bad Trips, and Growth

Psychedelics and Addiction Recovery: Alcohol and Death

DMT and Longevity: Limited Data and Receptor Similarities

Shrooms vs. LSD: Natural vs. Synthetic and Longevity Protocols

Part 4: Marijuana Analysis

Marijuana: Upsides, CBD vs. THC, and Consumer Control

Marijuana Downsides: Anxiety, Hyperemesis Syndrome, and Epigenetic Aging

Marijuana and Sleep: Mixed Findings and Individual Variability

Marijuana Research: Cultural Norms, Complex Mechanisms, and Snoop Dogg

Personal Experiences with Marijuana: Negative Effects and High Potency

Part 5: Summary, Rankings, Future

Psychedelics for Longevity: Ranking and Cautions

Precautions and Nuances: Medical Consultation and Positive Experiences

Future Topics and Closing Remarks: MDMA and Listener Engagement

Psilocybin, LSD & Marijuana: Ranking Drugs for Longevity (Part 2)

Bryan Johnson Podcast

Part 1: Introduction, Personal History

00:00Psychedelics and Longevity: An Introduction to Shrooms, LSD, DMT, and Marijuana

Psychedelics and Longevity: An Introduction to Shrooms, LSD, DMT, and Marijuana

01:52First Drug Experiences: Marijuana Encounters at Ages 13-15

First Drug Experiences: Marijuana Encounters at Ages 13-15

05:17Psychedelics in Society: Trauma Processing and Freedom of Thought

Psychedelics in Society: Trauma Processing and Freedom of Thought

Part 2: Philosophy, Therapy, Risks

07:53Psychedelics and "Don't Die" Ideology: Cultish Implications and Processing

Psychedelics and "Don't Die" Ideology: Cultish Implications and Processing

11:44Exploring Psychedelic Therapy: Death, Ibogaine Risks, and Ketamine

Exploring Psychedelic Therapy: Death, Ibogaine Risks, and Ketamine

Part 3: Psilocybin, LSD, DMT Research

13:36Psilocybin and Longevity: Mouse Studies and Potential Mechanisms

Psilocybin and Longevity: Mouse Studies and Potential Mechanisms

16:27Psilocybin Protocol Considerations: IRB Approval, Location, and Measurements

Psilocybin Protocol Considerations: IRB Approval, Location, and Measurements

19:17Psilocybin's Nuances: Telomere Elongation, Cellular Behavior, and Preliminary Research

Psilocybin's Nuances: Telomere Elongation, Cellular Behavior, and Preliminary Research

21:11Exploring Consciousness: Worms on LSD and the Limitations of Experience

Exploring Consciousness: Worms on LSD and the Limitations of Experience

23:59Psychedelics: Contraindications, Bad Trips, and Growth

Psychedelics: Contraindications, Bad Trips, and Growth

26:47Psychedelics and Addiction Recovery: Alcohol and Death

Psychedelics and Addiction Recovery: Alcohol and Death

29:27DMT and Longevity: Limited Data and Receptor Similarities

DMT and Longevity: Limited Data and Receptor Similarities

30:52Shrooms vs. LSD: Natural vs. Synthetic and Longevity Protocols

Shrooms vs. LSD: Natural vs. Synthetic and Longevity Protocols

Part 4: Marijuana Analysis

34:35Marijuana: Upsides, CBD vs. THC, and Consumer Control

Marijuana: Upsides, CBD vs. THC, and Consumer Control

36:50Marijuana Downsides: Anxiety, Hyperemesis Syndrome, and Epigenetic Aging

Marijuana Downsides: Anxiety, Hyperemesis Syndrome, and Epigenetic Aging

41:44Marijuana and Sleep: Mixed Findings and Individual Variability

Marijuana and Sleep: Mixed Findings and Individual Variability

44:49Marijuana Research: Cultural Norms, Complex Mechanisms, and Snoop Dogg

Marijuana Research: Cultural Norms, Complex Mechanisms, and Snoop Dogg

47:10Personal Experiences with Marijuana: Negative Effects and High Potency

Personal Experiences with Marijuana: Negative Effects and High Potency

Part 5: Summary, Rankings, Future

50:05Psychedelics for Longevity: Ranking and Cautions

Psychedelics for Longevity: Ranking and Cautions

52:44Precautions and Nuances: Medical Consultation and Positive Experiences

Precautions and Nuances: Medical Consultation and Positive Experiences

55:01Future Topics and Closing Remarks: MDMA and Listener Engagement

Future Topics and Closing Remarks: MDMA and Listener Engagement