The Sequential Organ Failure Assessment (SOFA)-2 Score

The podcast features an interview with Mervyn Singer, professor of intensive care medicine at University College London, focusing on the development and validation of the Sequential Organ Failure Assessment SOFA-2 score. The discussion centers on the updates made to the original SOFA score from 1996, driven by changes in medical practices such as the increased use of non-invasive ventilation and renal replacement therapy. The SOFA-2 score retains the original six organ systems but incorporates new interventions and adjusts thresholds based on data from 3.3 million patient episodes across multiple countries. While the new score addresses chronic organ dysfunction, Singer advises prospective studies to validate its use outside of intensive care settings.