GLP-1 agonist medications have been a popular topic of discussion recently. While this weight loss drug was designed for obesity, GLP-1 agonists like Ozempic have made their way into Hollywood. This has people questioning their safety and possible health risks, especially in the long run. Are GLP-1 agonists a quick fix for weight loss or a lifetime prescription? Who should be prescribed this medication, and what are the possible side effects?

This Longevity by Design episode features an interview with Dr. Spencer Nadolsky—An obesity and lipid specialist physician. Dr. Nadolsky explains how GLP-1 medications cause weight loss, answers questions about safety concerns, and discusses interesting patient stories about how people react to this medication. Dr. Nadolsky has a lot of patient experience with GLP-1 agonist drugs and is very knowledgeable about their current use and future potential.

Timestamps:

Introduction: (0:00–2:00)
Why Dr. Nadolsky became a physician: (2:00–4:13)
What is cardiometabolic medicine?: (4:13–5:17)
What is a “healthy” metabolism?: (5:17–7:37)
How does diet impact glucose regulation: (7:37–10:20)
Why has insulin resistance increased in the past decade?: (10:20–11:45)
Ethnicity impacts BMI cutoffs: (11:45–12:57)
Is obesity a choice?: (12:57–17:40)
How socioeconomic status impacts obesity: (17:40–21:30)
What's better: A BMI score or a DEXA scan?: (21:30–25:33)
How strength training improves healthspan: (25:33–32:32)
What a fasting insulin blood test tells you: (32:32–36:58)
Health risks of insulin resistance: (35:15–38:08)
How insulin resistance can increase ApoB: (38:08–39:25)
How does ApoB predict heart disease risk?: (39:25–42:50)
Why isn't ApoB included in typical lipid panels?: (42:50–44:25)
Behavioral science and clinical practice: (44:25–50:06)
How do GLP-1 agonists cause weight loss? (50:06–56:03)
Negative side effects of GLP-1 medications: (56:03–57:36)
Price of GLP-1s: (57:36–58:53)
GLP-1: A short term quick fix or a lifetime prescription?: (58:53–1:02:19)
Biggest health myths on social media: (1:02:19–1:08:45)
Top tip for healthspan: (1:08:45–end)

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How GLP-1 Agonists Are Changing Obesity Care with Dr. Spencer Nadolsky

Longevity by Design