Does Creatine have Cognitive Benefits? | Rhonda Patrick, Ph.D.

Peter Attia and Rhonda Patrick discuss the cognitive benefits of creatine, contrasting its measurable effects on physical performance with the more complex assessment of its impact on the brain. They emphasize that creatine's cognitive benefits are most apparent under conditions of stress, such as sleep deprivation, psychological strain, or aging, and that higher doses (e.g., 10-20 grams daily, split into multiple doses) are often necessary for brain uptake, as muscles are "greedy." They touch upon a pilot study showing cognitive improvement in Alzheimer's patients with high-dose creatine and discuss the importance of prevention, with Rhonda suggesting 10 grams a day could become the new baseline for cognitive support due to its perceived benefits and lack of downsides.