In this episode of The Human Upgrade, Dave Asprey delves into the science and practical applications of nicotine as a nootropic and potential longevity drug, distinguishing it from the dangers of smoking. He discusses the mechanisms through which nicotine affects the brain, its potential benefits for focus, memory, and neuroprotection, and emphasizes the importance of low dosing (under 10mg, ideally around 5mg) and cycling to avoid dependence and negative side effects. Asprey also covers various methods of nicotine delivery, the impact of genetics on nicotine metabolism, and how to stack nicotine with other supplements to enhance its effects, while cautioning against the use of products with artificial sweeteners and microplastics. He further explores the potential therapeutic uses of nicotine in conditions like Parkinson's, Alzheimer's, ADHD, and IBD, advocating for further research and a balanced perspective on its risks and benefits.
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