263. Cytokines Everywhere All at Once: Approach to CRS and ICANS

This podcast episode, titled "Cytokines Everywhere, All at Once, Approach to CRS and ICANS," focuses on Chimeric Antigen Receptor T-cell therapy (CAR-T) and its associated side effects: Cytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS). It details the pathophysiology, risk factors, grading systems, evaluation, and treatment approaches for CRS and ICANS, emphasizing the importance of early diagnosis and management. The episode also touches on the potential prophylactic use of anakinera for ICANS prevention and directs listeners to resources like institutional treatment algorithms and the CAR-TOCS app for guidance.