283. Putting out the Fire: A clinical approach to Adult Onset Still’s Disease

Adult Onset Still's Disease, an autoimmune condition marked by systemic inflammation, is explored, likening the disease's progression to a house fire ignited by a small ember. The podcast details the disease's presentation, often mimicking a fever of unknown origin, and highlights key symptoms such as recurring fevers, a salmon-colored rash, pharyngitis, and joint pain. It emphasizes the importance of excluding other conditions, including Macrophage Activation Syndrome (MAS), and outlines diagnostic steps, including lab work and imaging. Treatment strategies range from NSAIDs and corticosteroids to immunomodulatory medications and biologics for severe cases, alongside the Yamaguchi Criteria for classification, which involves major and minor clinical features.