Karl Herrup, "How Not to Study a Disease: The Story of Alzheimer's" (MIT Press, 2021)

This podcast episode features Galina Limorenko interviewing Karl Herrup, a neurobiologist, about his book, "How Not to Study a Disease: The Story of Alzheimer's." Herrup discusses the challenges in Alzheimer's research, including the dominance of the amyloid cascade hypothesis, and the gaps in understanding the disease from the perspectives of physicians, researchers, patients, and their families. He touches on the role of pharmaceutical companies, the FDA's approval of aducanumab, and the importance of basic research and understanding the biology of aging. He also shares his personal journey into Alzheimer's research and offers advice to young researchers.

Outlines

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New Books in Science

Introduction to NBN Productions

Introduction to the Episode and Guest

Karl Herrup's Background and Interest in Science

The Genesis of "How Not to Study a Disease"

Defining Alzheimer's Disease and Differing Perceptions

Gaps in Understanding and the Problem with the Biological Definition

The Amyloid Cascade Hypothesis and Alternative Theories

The Resilience of the Amyloid Cascade Hypothesis and the Need for a Reset

The Role and Responsibility of Biotech and Pharma Industries

The Aducanumab Controversy and its Implications

Ramifications for Other Amyloid-Clearing Antibodies and the Risk to Public Confidence

The Roles of Universities and Governments in Subsidizing Research

The Influence of Political, Economic, and Social Forces

Preventative Measures and the Need to Change Pharmaceutical Models

Surprising Discoveries, Personal Habits, and Future Projects

Karl Herrup, "How Not to Study a Disease: The Story of Alzheimer's" (MIT Press, 2021)

New Books in Science

00:00Introduction to NBN Productions

Introduction to NBN Productions

01:06Introduction to the Episode and Guest

Introduction to the Episode and Guest

04:10Karl Herrup's Background and Interest in Science

Karl Herrup's Background and Interest in Science

08:37The Genesis of "How Not to Study a Disease"

The Genesis of "How Not to Study a Disease"

11:35Defining Alzheimer's Disease and Differing Perceptions

Defining Alzheimer's Disease and Differing Perceptions

15:14Gaps in Understanding and the Problem with the Biological Definition

Gaps in Understanding and the Problem with the Biological Definition

19:02The Amyloid Cascade Hypothesis and Alternative Theories

The Amyloid Cascade Hypothesis and Alternative Theories

22:26The Resilience of the Amyloid Cascade Hypothesis and the Need for a Reset

The Resilience of the Amyloid Cascade Hypothesis and the Need for a Reset

24:45The Role and Responsibility of Biotech and Pharma Industries

The Role and Responsibility of Biotech and Pharma Industries

27:51The Aducanumab Controversy and its Implications

The Aducanumab Controversy and its Implications

30:48Ramifications for Other Amyloid-Clearing Antibodies and the Risk to Public Confidence

Ramifications for Other Amyloid-Clearing Antibodies and the Risk to Public Confidence

33:05The Roles of Universities and Governments in Subsidizing Research

The Roles of Universities and Governments in Subsidizing Research

37:33The Influence of Political, Economic, and Social Forces

The Influence of Political, Economic, and Social Forces

41:41Preventative Measures and the Need to Change Pharmaceutical Models

Preventative Measures and the Need to Change Pharmaceutical Models

43:29Surprising Discoveries, Personal Habits, and Future Projects

Surprising Discoveries, Personal Habits, and Future Projects