Episode 14: Opioids part 2

In this episode of the ACCRAC podcast, Jed Wolpaw concludes a two-part series on opiates by delving into their pharmacokinetics, pharmacodynamics, and various applications, including their use in analgesia, anesthesia, and transdermal patches. He discusses the impact of factors like lipid solubility, liver and kidney function, age, and pH on opiate action, as well as the nuances of different opioids such as morphine, fentanyl, and remifentanil. The episode also covers opioid agonist-antagonists like buprenorphine and naloxone, highlighting their mechanisms and clinical considerations, and concludes with a review of opiate interactions with other medications, such as propofol, ketamine, and tricyclic antidepressants.