Lactate: The Key to Metabolic Health, Mitochondria, and Longevity | Dr Iñigo San Millán | The Proof with Simon Hill

In this interview, Simon Hill and Dr. Inigo San Milan discuss lactate, challenging the outdated idea of it being a metabolic waste product. They explore lactate's role as a signaling molecule and fuel source, highlighting its importance in mitochondrial health and metabolic flexibility. The conversation covers how lactate contributes to glucose intolerance and type 2 diabetes, emphasizing the benefits of Zone 2 training for improving lactate clearance and enhancing endurance performance. They also touch on the limitations of VO2 max as a marker of mitochondrial health and the potential drawbacks of low-carb diets, advocating for a balanced approach to exercise and nutrition for optimal metabolic health and disease prevention.

Outlines

Sign in to continue reading, translating and more.

Continue

Lactate: The Key to Metabolic Health, Mitochondria, and Longevity | Dr Iñigo San Millán

The Proof with Simon Hill

Introduction to Lactate: Challenging Old Beliefs

Lactate as Fuel and Debunking Myths

The Role of Lactate in Glucose Metabolism and Mitochondrial Function

Lactate Levels as Indicators of Metabolic Stress and Mitochondrial Function

Lifestyle Modulation of Mitochondrial Function and Glucose Metabolism

Using Lactate to Assess Metabolic Risk and the Role of Exercise

The Benefits of Fat Oxidation and Lactate's Signaling Role

High-Intensity Exercise and Lactate Shuttling

Training Intensity Distribution and VO2 Max

Mitochondrial Function and Disease Prevention

Exercise Recommendations and Resistance Training

Sex Differences and Dietary Considerations

The Impact of Low-Carb Diets on Mitochondrial Function

Addressing Criticisms of Zone 2 Training

The Power of Exercise for Longevity and Concluding Remarks

Lactate: The Key to Metabolic Health, Mitochondria, and Longevity | Dr Iñigo San Millán

The Proof with Simon Hill

00:00Introduction to Lactate: Challenging Old Beliefs

Introduction to Lactate: Challenging Old Beliefs

05:27Lactate as Fuel and Debunking Myths

Lactate as Fuel and Debunking Myths

09:55The Role of Lactate in Glucose Metabolism and Mitochondrial Function

The Role of Lactate in Glucose Metabolism and Mitochondrial Function

15:02Lactate Levels as Indicators of Metabolic Stress and Mitochondrial Function

Lactate Levels as Indicators of Metabolic Stress and Mitochondrial Function

18:33Lifestyle Modulation of Mitochondrial Function and Glucose Metabolism

Lifestyle Modulation of Mitochondrial Function and Glucose Metabolism

27:59Using Lactate to Assess Metabolic Risk and the Role of Exercise

Using Lactate to Assess Metabolic Risk and the Role of Exercise

35:57The Benefits of Fat Oxidation and Lactate's Signaling Role

The Benefits of Fat Oxidation and Lactate's Signaling Role

42:24High-Intensity Exercise and Lactate Shuttling

High-Intensity Exercise and Lactate Shuttling

47:51Training Intensity Distribution and VO2 Max

Training Intensity Distribution and VO2 Max

54:23Mitochondrial Function and Disease Prevention

Mitochondrial Function and Disease Prevention

1:02:02Exercise Recommendations and Resistance Training

Exercise Recommendations and Resistance Training

1:07:26Sex Differences and Dietary Considerations

Sex Differences and Dietary Considerations

1:11:17The Impact of Low-Carb Diets on Mitochondrial Function

The Impact of Low-Carb Diets on Mitochondrial Function

1:16:23Addressing Criticisms of Zone 2 Training

Addressing Criticisms of Zone 2 Training

1:23:51The Power of Exercise for Longevity and Concluding Remarks

The Power of Exercise for Longevity and Concluding Remarks