76: Pièce de (Gram-negative) Resistance, Part 1: AmpC, ESBL

This episode of Febrile, a podcast about infectious diseases, features a discussion on resistant Gram-negatives, specifically Enterobacterales, ESBLs, AmpC organisms, and CREs. The hosts, along with guest expert Dr. Pranita Tamma, delve into reading susceptibility patterns, antibiotic choices, and the implications of the updated IDSA guidance on antimicrobial-resistant Gram-negative infections. Through case studies, they explore treatment options, the role of cefepime and carbapenems, and the challenges posed by organisms like Klebsiella aerogenes and Morganella morganii. The episode also addresses the complexities of AmpC production and the limitations of older acronyms used to classify these organisms, providing insights into current approaches and evolving data in antimicrobial stewardship.

Outlines

Part 1: Introduction and Guidance

Part 2: Case Studies - ESBL and AmpC

Part 3: Key Takeaways

Sign in to continue reading, translating and more.

Continue

Febrile

Part 1: Introduction and Guidance

Introduction to Resistant Gram-Negatives and IDSA Guidance Update

Key Updates in the 2023 IDSA Guidance

Part 2: Case Studies - ESBL and AmpC

Case 1: Approach to Ceftriaxone-Resistant E. coli Pyelonephritis

Case 1 Continued: Alternative Treatment Options and Introduction to AmpC Organisms

Case 2: Understanding and Managing AmpC-Producing Organisms

Case 2 Continued: Piperacillin-Tazobactam for AmpC Organisms and Introduction to Case 3

Case 3: Ceftriaxone Use in Morganella Infections and Episode Wrap-up

Part 3: Key Takeaways

Summary of Key Take-Home Points and Episode Conclusion

76: Pièce de (Gram-negative) Resistance, Part 1: AmpC, ESBL

Febrile

Part 1: Introduction and Guidance

00:08Introduction to Resistant Gram-Negatives and IDSA Guidance Update

Introduction to Resistant Gram-Negatives and IDSA Guidance Update

04:16Key Updates in the 2023 IDSA Guidance

Key Updates in the 2023 IDSA Guidance

Part 2: Case Studies - ESBL and AmpC

06:46Case 1: Approach to Ceftriaxone-Resistant E. coli Pyelonephritis

Case 1: Approach to Ceftriaxone-Resistant E. coli Pyelonephritis

14:45Case 1 Continued: Alternative Treatment Options and Introduction to AmpC Organisms

Case 1 Continued: Alternative Treatment Options and Introduction to AmpC Organisms

22:35Case 2: Understanding and Managing AmpC-Producing Organisms

Case 2: Understanding and Managing AmpC-Producing Organisms

34:24Case 2 Continued: Piperacillin-Tazobactam for AmpC Organisms and Introduction to Case 3

Case 2 Continued: Piperacillin-Tazobactam for AmpC Organisms and Introduction to Case 3

41:13Case 3: Ceftriaxone Use in Morganella Infections and Episode Wrap-up

Case 3: Ceftriaxone Use in Morganella Infections and Episode Wrap-up

Part 3: Key Takeaways

49:50Summary of Key Take-Home Points and Episode Conclusion

Summary of Key Take-Home Points and Episode Conclusion