108: StAR: MDR GN

In this episode of Thug Rile, host Sarah Dong welcomes Arsheena Yassin and Mariya Huralska to discuss multidrug-resistant gram-negative infections, focusing on clinical reasoning, diagnostics, and antimicrobial management. The discussion begins with a case of an 82-year-old female with multiple comorbidities presenting with pneumonia, complicated by a history of antibiotic use and resistant infections. The guests emphasize the importance of detailed patient history, local epidemiology, and risk factor assessment in choosing empiric therapy. They cover diagnostic approaches, including rapid diagnostic testing, and stress the need for antimicrobial stewardship. The episode concludes with a discussion on optimizing antibiotic dosing, the role of a multidisciplinary team in patient management, and ensuring safe transitions to outpatient care, highlighting the challenges and strategies in treating these complex infections.