IBCC Episode 19 - Severe Influenza

In this episode of The Internet Book of Critical Care Podcast, Josh and Adam delve into the complexities of severe influenza in the ICU, acknowledging the limited evidence base while exploring various aspects of management. They discuss the significant burden of influenza on healthcare systems, diagnostic challenges, and the importance of avoiding aggressive fluid resuscitation. The conversation covers antibacterial and antiviral therapies, including the potential benefits of clarithromycin and naproxen, and addresses respiratory support strategies. Furthermore, they explore adjuvant therapies like steroids and vitamin C, and introduce the concept of virus-associated hemophagocytic syndrome (HLH), emphasizing the need for monitoring and considering treatment options in severe cases while also acknowledging the spectrum of severe inflammation.