The podcast explores fluid selection and pH-guided resuscitation in critical care. It emphasizes the importance of choosing the optimal resuscitation fluid, moving beyond normal saline to balanced crystalloids, and tailoring fluid selection to a patient's pH status. The discussion covers crystalloids versus colloids, highlighting the dangers of head of starch and the limited role of albumin. Arguments for and against saline are examined, including cost, hyperkalemia, and hemodynamic instability. The hosts advocate for pH-guided resuscitation, detailing when to alkalize with isotonic bicarbonate (for non-anion gap metabolic acidosis or uremic acidosis) or acidify with normal saline (for acute metabolic alkalosis), versus maintaining with balanced crystalloids. The hosts also discuss the nuances of hypertonic versus isotonic bicarbonate and common errors in bicarbonate use.
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