#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More | The Tim Ferriss Show

In this episode of the Tim Ferriss Show, Tim interviews Dr. Dominic D'Agostino, a returning guest and expert on ketosis, the ketogenic diet, and metabolic therapies. They discuss the potential applications of the ketogenic diet and exogenous ketones for neurodegenerative diseases like Alzheimer's, preventative measures, and symptom mitigation. Dom shares his insights on metabolic psychiatry, cancer research, and personal health protocols, including sardine fasting, supplementation, and the use of hyperbaric oxygen treatment. They delve into the nuances of ketone measurement, the importance of monitoring metabolic biomarkers, and the potential benefits and risks of various dietary and lifestyle interventions. Dom also shares his personal dietary habits, supplement regimen, and even his approach to optimizing his dogs' health.

Outlines

Part 1: Introduction and Key Concepts

Part 2: Alzheimer's and Brain Metabolism

Part 3: Fasting and Cancer

Part 4: Glucose Monitoring and Ketone Memory

Part 5: Diet, Supplements, and Dog Nutrition

Part 6: Sleep, Immune Regulation, and Meal Timing

Part 7: Practical Keto Tips and MCT

Part 8: Future Research and Metabolic Psychiatry

Part 9: Ketogenic Therapies and Supplements

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#825: Dr. Dominic D’Agostino — All Things Ketones, How to Protect the Brain and Boost Cognition, Sardine Fasting, Diet Rules, Revisiting Metformin and Melatonin, and More

The Tim Ferriss Show

Part 1: Introduction and Key Concepts

00:00Introduction to Ketosis, Metabolic Psychiatry, and Dr. D'Agostino's Expertise

Introduction to Ketosis, Metabolic Psychiatry, and Dr. D'Agostino's Expertise

01:34Key Takeaways: Supplemental Ketones, MCT Oil, and the Benefits of Ketones

Key Takeaways: Supplemental Ketones, MCT Oil, and the Benefits of Ketones

05:06Risks of Ketone Supplements, Metabolic Zone, and Anxiety

Risks of Ketone Supplements, Metabolic Zone, and Anxiety

07:28Soluble Fiber, Hyperbaric Oxygen Treatment, and Melatonin

Soluble Fiber, Hyperbaric Oxygen Treatment, and Melatonin

Part 2: Alzheimer's and Brain Metabolism

14:42Introduction to Alzheimer's Research and Preventative Measures

Introduction to Alzheimer's Research and Preventative Measures

16:13Early Adopters, Brain Energy Metabolism, and Alzheimer's Disease

Early Adopters, Brain Energy Metabolism, and Alzheimer's Disease

18:35Amyloid Plaque, Glucose Hypometabolism, and Neuroinflammation in Alzheimer's

Amyloid Plaque, Glucose Hypometabolism, and Neuroinflammation in Alzheimer's

20:20Infection as an Ideological Agent for Alzheimer's Disease

Infection as an Ideological Agent for Alzheimer's Disease

Part 3: Fasting and Cancer

21:56Measuring Ketones and Comparing Fasting Methods

Measuring Ketones and Comparing Fasting Methods

23:42Sardine Fasting and Dr. Fred Hatfield's Cancer Remission

Sardine Fasting and Dr. Fred Hatfield's Cancer Remission

26:08Prostate Cancer Remission and Frequency of Sardine Fasting

Prostate Cancer Remission and Frequency of Sardine Fasting

28:31Tim's Hiatal Hernia and Fasting for Cancer Risk Reduction

Tim's Hiatal Hernia and Fasting for Cancer Risk Reduction

30:03Situational Fasting and HSCRP as a Cardiometabolic Biomarker

Situational Fasting and HSCRP as a Cardiometabolic Biomarker

31:32Sardine Fasting for Cancer Patients and Autophagy

Sardine Fasting for Cancer Patients and Autophagy

Part 4: Glucose Monitoring and Ketone Memory

33:09Glucose Readings and the Keto-Mojo Device

Glucose Readings and the Keto-Mojo Device

34:00Accuracy of Glucose Meters and Hemoglobin A1c

Accuracy of Glucose Meters and Hemoglobin A1c

35:21Oral Glucose Tolerance Test and CGM

Oral Glucose Tolerance Test and CGM

38:38Exogenous Ketones and Keto Memory

Exogenous Ketones and Keto Memory

40:38Low-Carb Mediterranean Diet and Metabolic Biomarkers

Low-Carb Mediterranean Diet and Metabolic Biomarkers

Part 5: Diet, Supplements, and Dog Nutrition

42:06Hyperabsorbers and Cholesterol Management

Hyperabsorbers and Cholesterol Management

44:07Carbohydrate Intake and Fiber

Carbohydrate Intake and Fiber

45:55Dietary Changes and Dog Nutrition

Dietary Changes and Dog Nutrition

47:21SARMs, Rapamycin, and Dog Health

SARMs, Rapamycin, and Dog Health

49:31SARMs Explained and Dog Optimization

SARMs Explained and Dog Optimization

Part 6: Sleep, Immune Regulation, and Meal Timing

51:30Supplementation for Ketogenic Diets and Fasting

Supplementation for Ketogenic Diets and Fasting

53:34Diphenhydramine, Melatonin, and Sleep Aids

Diphenhydramine, Melatonin, and Sleep Aids

55:34Melatonin and Endocrine Disruption

Melatonin and Endocrine Disruption

59:04Water Fasting vs. Sardine Fasting and Shingles

Water Fasting vs. Sardine Fasting and Shingles

1:00:32Metabolic Control of Immune Regulation

Metabolic Control of Immune Regulation

1:02:30Multifactorial Effects of Ketogenic Therapies

Multifactorial Effects of Ketogenic Therapies

1:04:11Dom's Current Diet and Meal Timing

Dom's Current Diet and Meal Timing

1:05:57Wine Consumption and Platelet Aggregation

Wine Consumption and Platelet Aggregation

Part 7: Practical Keto Tips and MCT

1:07:34Fiber Intake and Tips for Novices on the Ketogenic Diet

Fiber Intake and Tips for Novices on the Ketogenic Diet

1:09:21Adaptation to Ketosis and MCT

Adaptation to Ketosis and MCT

1:11:15MCT Oil and Powder Recommendations

MCT Oil and Powder Recommendations

1:12:41MCT Oil Powders and Travel