Karl Friston is one of the most influential neuroscientists alive. He pioneered the methods that underpin modern brain imaging and developed the Free Energy Principle—considered by many neuroscientists to be the closest thing we have to a general theory of intelligence.

In this conversation with Dr. Michael Mannino and me, Friston explains why your brain doesn’t just record reality—it invents it. Perception is best understood as a “controlled hallucination”: the brain generates models of the world, then tests them against incoming data.

We dig into what this means for consciousness, resilience, and performance.

Why intuition works as your brain’s shortcut for reducing uncertainty
How flow states and psychedelics both relax rigid brain assumptions—unlocking clarity and creativity

Why mental health challenges like depression, PTSD, and addiction often stem from overly rigid neural networks.

How attention functions as a lever for healing, flexibility, and peak performance

Friston shows how predictive coding and metastability express ancient evolutionary mechanisms for creativity, resilience, and recovery—and how new science helps us apply these processes to amplify health and performance over time.

If you want a deeper grasp of how your brain constructs reality—and how to shape that construction through flow—this is the episode to watch.

Guest Bio: Dr. Karl Friston is a theoretical neuroscientist and one of the most influential figures in modern brain science. He invented statistical parametric mapping, voxel-based morphometry, and dynamic causal modeling—methods that have become foundational to brain imaging. He also developed the Free Energy Principle, a unifying framework for action and perception that’s been called the closest thing we have to a general theory of intelligence.

Across his career, Karl has earned nearly every major accolade in neuroscience, from the Minerva Golden Brain Award to the Glass Brain Award for lifetime achievement in human brain mapping. He’s a Fellow of the Royal Society, the Royal Society of Biology, the Academia Europaea, and EMBO.

And he’s also a collaborator with us here at the Flow Research Collective. Together we’ve published two recent papers—just last week in Nature: Communications Biology on Pathfinding: a neurodynamical account of intuition, and earlier in Neuroscience of Consciousness on Flow and intuition: a systems neuroscience comparison.

In This Episode:

05:38 Birth of the Free Energy Principle

09:09 Theoretical vs. Computational Neuroscience

11:06 What the Free Energy Principle Actually Means

17:42 Intuition as Inference

24:15 Flow, Uncertainty, and Prediction

29:39 Flow, Psychedelics & PTSD

38:12 Cognitive Bias & Relaxing Priors

49:55 Flow as Neuroprotective

1:03:20 Metastability: The Brain’s Flexibility Principle

1:12:36 From Theory to Practice

Episode Resources:

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How Your Brain Predicts Reality | Flow, Intuition & Mental Flexibility

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