TWiV 1239: Aluminum and antibodies

In this episode of TWiV, Vincent Racaniello, Alan Dove, and Brianne Barker discuss virology and immunology news, beginning with a discussion on the safety of aluminum adjuvants in vaccines, referencing a Danish study that found no increased risk of chronic diseases in children receiving aluminum-adsorbed vaccines. They then delve into a paper on the structural serology of polyclonal antibody responses to mRNA-1273 (Moderna) and Novavax COVID-19 vaccines, exploring the epitope distribution and antibody responses in non-human primates and humans, and the implications for future vaccine design. Finally, they answer listener emails on topics ranging from vaccine skepticism among doctors to the state of scientific research in the U.S., and share their "picks of the week," including an animation of MHC class one antigen presentation, a thought-provoking online game, and a promising new HIV antiviral drug.

Outlines

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This Week in Virology

Introduction and Podcast Overview

Addressing Concerns About Aluminum in Vaccines

Analyzing a Danish Study on Aluminum Adsorbed Vaccines and Childhood Diseases

Findings and Implications of the Danish Aluminum Vaccine Study

Introduction to Structural Serology of COVID-19 Vaccines

Epitope Structure and Antibody Responses to SARS-CoV-2

Vaccine Responses and Variant Reactivity in Non-Human Primates

Human Clinical Trial Data and Vaccine Modalities

Implications for Future Vaccine Design

Listener Emails: Pathologist's Opinion on Vaccines and COVID-19 in Russia

Listener Emails: SARS-CoV-2 Origin and State Income Taxes

Listener Emails: The Future of Science and the Chilean Soapbark Tree

Listener Emails: Herd Immunity in Farm Animals

Listener Emails: Mnemonics and Cells at Work

Picks of the Week and Closing Remarks

TWiV 1239: Aluminum and antibodies

This Week in Virology

00:00Introduction and Podcast Overview

Introduction and Podcast Overview

05:31Addressing Concerns About Aluminum in Vaccines

Addressing Concerns About Aluminum in Vaccines

11:14Analyzing a Danish Study on Aluminum Adsorbed Vaccines and Childhood Diseases

Analyzing a Danish Study on Aluminum Adsorbed Vaccines and Childhood Diseases

22:04Findings and Implications of the Danish Aluminum Vaccine Study

Findings and Implications of the Danish Aluminum Vaccine Study

27:15Introduction to Structural Serology of COVID-19 Vaccines

Introduction to Structural Serology of COVID-19 Vaccines

37:34Epitope Structure and Antibody Responses to SARS-CoV-2

Epitope Structure and Antibody Responses to SARS-CoV-2

47:14Vaccine Responses and Variant Reactivity in Non-Human Primates

Vaccine Responses and Variant Reactivity in Non-Human Primates

55:01Human Clinical Trial Data and Vaccine Modalities

Human Clinical Trial Data and Vaccine Modalities

1:07:11Implications for Future Vaccine Design

Implications for Future Vaccine Design

1:11:54Listener Emails: Pathologist's Opinion on Vaccines and COVID-19 in Russia

Listener Emails: Pathologist's Opinion on Vaccines and COVID-19 in Russia

1:20:00Listener Emails: SARS-CoV-2 Origin and State Income Taxes

Listener Emails: SARS-CoV-2 Origin and State Income Taxes

1:25:27Listener Emails: The Future of Science and the Chilean Soapbark Tree

Listener Emails: The Future of Science and the Chilean Soapbark Tree

1:33:07Listener Emails: Herd Immunity in Farm Animals

Listener Emails: Herd Immunity in Farm Animals

1:37:14Listener Emails: Mnemonics and Cells at Work

Listener Emails: Mnemonics and Cells at Work

1:42:56Picks of the Week and Closing Remarks

Picks of the Week and Closing Remarks