Lactic Acidosis - Type B

The podcast explores Type B lactic acidosis, differentiating it from Type A, which results from inadequate oxygen delivery. Type B is categorized into B1 (underlying diseases), B2 (drugs and toxins), and B3 (inborn metabolism errors). Examples of B1 include renal and hepatic failure, diabetes, and malignancies, with specific cancers linked to high lactate levels and mortality. B2 causes include acetaminophen, epinephrine, cocaine, halothane, metformin, propofol, and linazolid. The podcast highlights propofol infusion syndrome and the dangers of cocaine and methamphetamine. Finally, it touches on rare inborn metabolism errors (B3) and D-lactic acidosis, emphasizing that D-lactate itself can be pathological, causing neurological issues, especially in patients with short bowel syndrome, and is treated with dietary changes and antibiotics.