In this episode, Jason Fung, nephrologist and best-selling author, shares his experiences utilizing an individualized approach to fasting to successfully treat thousands of overweight, metabolically ill, and diabetic patients, and why being a doctor who specializes in kidney disease gives him a unique insight into early indications of metabolic disease. We also have a great discussion on insulin resistance where Jason makes the case that we should actually think of hyperinsulinemia as the underlying problem. We also discuss the difference between time-restricted feeding, intermittent fasting, and dietary restriction (e.g., low-carb) and how they can be used to attack the root cause of T2D, metabolic syndrome, and obesity. We also have a fascinating discussion about the limitations of evidence-based medicine which leads to a conversation where we compare and contrast the scientific disciplines of medicine and biology to theoretical physics.

We discuss:

Comparing scientific disciplines: Medicine and biology versus physics [4:00];
The limitations of evidence-based medicine [9:00];
Early signs of metabolic disease: How specializing kidney disease gives Jason a unique insight into early indications of illness [17:10]
Insulin resistance, hyperinsulinemia, and the overflow paradigm [26:00];
Why the common treatments for type 2 diabetes seem to make things worse [39:00];
How hyperinsulinemia (not insulin resistance) drives metabolic syndrome [49:45];
Insulin and weight gain, and using fasting to empty the cells of glucose [56:00];
The two step process of developing type 2 diabetes and how they are both manifestations of hyperinsulinemia [59:45];
NAFLD and hyperinsulinemia: A vicious cycle [1:05:00];
Are the features and symptoms of diabetes actually protective? [1:08:45];
Is obesity causing insulin resistance or is it the other way around? [1:14:00];
What role does inflammation play in obesity? [1:18:15];
CVD and cancer: Diseases of too much growth? [1:24:00];
How to reduce proliferation with rapamycin, nutrition, exercise, fasting, and manipulating hormones [1:29:15];
Getting patients to fast: How Jason and Peter utilize fasting in their practice, and how their approach differs [1:36:45];
Comparing bariatric surgery to fasting as a treatment for type 2 diabetes [1:44:30];
Why people think that fasting is bad for you [1:21:45];
Time-restricted feeding and intermittent fasting: Defining terms, and how Jason applies them in his practice [1:55:00];
A fasting case study: A diabetic patient with a non-healing foot ulcer [2:00:30];
Keys to a successful fast [2:09:15];
Muscle loss during fasting, and why Jason isn’t worried [2:21:15];
Will fasting help a healthy person live longer? [2:28:00];
Does fasting cause gallstones? [2:35:15]; and
More.

#59 - Jason Fung, M.D.: Fasting as a potent antidote to obesity, insulin resistance, type 2 diabetes, and the many symptoms of metabolic illness

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