This edition of NPR's "Up First" covers several developing news stories. The podcast begins with a discussion on the escalating conflict between Israel and Iran, analyzing the missile capabilities of both sides and the potential impact on civilian lives, featuring insights from NPR's Kat Lonsdorf. The conversation shifts to President Trump's push for a massive tax cut and spending bill, the internal divisions within the Republican party, and the potential challenges in passing the bill, with NPR congressional correspondent Deidre Walsh providing updates. Finally, the podcast addresses the impending heat wave and high humidity expected to affect millions of Americans, with meteorologist Ben Noll explaining the causes and dangers of the extreme weather. The episode concludes with a segment from NPR's "Wait, Wait, Don't Tell Me," a lighthearted news quiz.