In this episode of the Odd Lots podcast, Joe Weisenthal interviews Gappy Paleologo, Global Head of Quantitative Research at Balyasny Asset Management, about quantitative investing. Paleologo defines quantitative investing, differentiating between factors and themes, and explains his role at Balyasny, which involves developing factor models, hedging, and portfolio advisory services. The conversation explores how new factors are identified, the importance of proprietary data, and the impact of AI and machine learning on investment strategies. They also discuss the challenges of regime changes and the relevance of traditional factors like value and momentum in today's market, as well as the definition of alpha.