In this episode of the Joe Rogan Experience, Joe interviews Beth Shapiro, a paleogeneticist and chief science officer at Colossal. They discuss ancient DNA, the process of extracting it, and the challenges and controversies surrounding the field, including gatekeeping in academia. Beth recounts her journey from broadcast journalism to science, her experiences in Siberia studying ancient DNA, and Colossal's work on de-extinction, specifically the dire wolf project. They explore the ethical implications of de-extinction, the impact of invasive species, and the potential for genetic rescue in conservation efforts. They also touch on various topics such as the history of humans, the nature of species, and the potential for genetic engineering to cure diseases.