Up First from NPR News presents a summary of current events for the day. The podcast begins with the escalating conflict between Israel and Iran, including details of attacks on Iranian state TV and the anxieties of Tehran residents. It then shifts to the political assassination in Minnesota, detailing the charges against the suspect, the evidence found, and the targeted nature of the attacks. Finally, the podcast discusses the opioid settlement reached with Purdue Pharma and the Sackler family, outlining the terms of the deal, how the money will be spent, and the lingering questions about justice for those affected by the opioid crisis. The episode concludes with a segment from NPR's Shortwave podcast, exploring the feasibility of a U.S. missile defense system similar to Israel's Iron Dome.