Shaan and Sam explore business opportunities related to "butts and guts," starting with the twerking fitness trend and its brief moment in the spotlight. They then discuss fecal microbiota transplants and the potential for selling elite athletes' microbiomes to enhance endurance. The conversation shifts to the history and cultural significance of butts, leading to the booming business of Brazilian butt lifts (BBLs) and related recovery products. They analyze the turnaround of the dating app Grindr, highlighting its unique user experience and financial success. The hosts also touch on DUDE Wipes, bidet companies like TUSHY, and specialized colon health clinics, illustrating the diverse ways entrepreneurs are capitalizing on these markets. They share personal anecdotes, discuss the importance of learning from others, and reflect on their own motivations for success.