This NPR news podcast, "Up First," presents three main news stories. First, it covers President Trump's deployment of active-duty Marines and additional National Guard troops to Los Angeles in response to immigration protests, detailing the concerns of California's governor and local officials about unnecessary escalation. Second, it discusses HHS Secretary Robert F. Kennedy Jr.'s removal of all members of a CDC vaccine advisory committee, highlighting the alarm within the medical community and potential impacts on vaccine policy. Finally, the podcast reports on the hopeful trend of decreasing fentanyl overdose deaths among young people in the U.S., while also noting concerns about potential budget cuts that could threaten this progress.