In this episode of ZOE Science & Nutrition, Jonathan Wolfe is joined by Professors Tim Spector and Sarah Berry to discuss the role of supplements in modern diets. They address common misconceptions, such as the idea that supplements can provide the same benefits as whole foods or that excessive amounts of vitamins are beneficial, and discuss how the historical context of vitamin deficiencies differs greatly from today's nutritional challenges, where the focus should be on addressing fiber deficiencies and improving gut health. They introduce a new approach to supplementation, highlighting a clinical trial on a prebiotic gut supplement that showed promising results in improving gut microbiome composition, mood, energy levels, and even reducing cholesterol and inflammation in certain individuals, suggesting a shift towards supplements that address modern dietary needs rather than historical deficiencies.