David Friedberg interviews Jared Isaacman, a successful entrepreneur and space enthusiast, about his nomination to lead NASA, which was later withdrawn. They discuss Isaacman's background, including his business ventures, aviation experience, and space missions like Inspiration4 and Polaris Dawn. The conversation explores Isaacman's views on NASA's bureaucracy, the space race with China, and the role of commercial space companies like SpaceX. Isaacman shares his perspective on the Trump administration's proposed budget cuts for NASA and the reasons behind the withdrawal of his nomination, suggesting it may have been related to anti-Elon sentiment within the administration. He emphasizes the importance of focusing NASA's efforts on projects that commercial companies cannot undertake, such as nuclear propulsion, and expresses concern about the growing national debt and the need for government efficiency.