In this episode of the a16z Podcast, Marc Andreessen reflects on the evolution of Andreessen Horowitz (a16z) from its early days to its current multi-stage, multi-sector platform. He discusses raising the first fund during the 2008 financial crisis, the shift from generalist to vertical expert investors, and the firm's "Little Tech" agenda, which aims to reframe policy conversations around innovation and AI. Andreessen also shares insights on the early challenges and skepticism faced by Facebook, including a near acquisition by Yahoo, and touches on the broader themes of globalization, tech regulation, and the changing relationship between Silicon Valley and the defense sector.