The GU Cast podcast episode features Michael Hofman, Declan Murphy, Ed Kwan, and Louise Kostos discussing PSMA (Prostate-Specific Membrane Antigen) biology and theranostics in prostate cancer. The discussion includes presentations from Misha Beltran, Louise Emmett, Ed Kwan, and Marty Pomper, covering topics such as PSMA heterogeneity, upregulation of PSMA receptors, ctDNA as a predictive biomarker, and insights gained from decades of PSMA research. The panelists address questions about PSMA expression, treatment resistance, appropriate radiotracers, and the potential for personalized theranostic approaches, highlighting the importance of new targets, biomarkers, and imaging techniques in advancing prostate cancer treatment. The Prostate Cancer Foundation (PCF) is acknowledged for its support of research in this area.
