This edition of NPR's "Up First" covers several developing news stories. The podcast begins with a discussion on the distribution of aid in Gaza, where a new U.S.-backed plan has led to chaos and violence, with reports of Israeli forces firing at crowds swarming a food distribution site. The conversation includes insights from NPR correspondent Eya Batraoui, who details the lack of a proper distribution system and the dire humanitarian situation. Next, the hosts discuss updated COVID-19 vaccine guidelines, where federal health officials no longer recommend routine vaccination for healthy children and pregnant women, a decision that has raised concerns among independent experts. Finally, the podcast addresses the situation in Syrian detention camps holding relatives of ISIS fighters, focusing on efforts to repatriate children and the challenges of potential radicalization.