This podcast episode delves into the potential of northern ecosystems, particularly the Canadian North, in yielding wonder drugs derived from unique chemicals. Exploring unknown chemicals in these harsh conditions has led to the discovery of novel substances with remarkable properties, including 13 new compounds from the stereocolon pascali lichen. The Arctic region harbors fascinating lichens and fungi that produce unique natural substances with the potential to be developed into life-saving drugs such as anti-inflammatory agents and cancer-fighting drugs. However, the alarming transformation of the Arctic due to climate change poses a significant threat to this biodiversity, resulting in the loss of potential wonder drugs.