TWiV 1221: Nonsense mediated decay

In this episode of "This Week in Virology," Vincent Racaniello, Alan Dove, and Angela Mingarelli discuss recent news regarding science funding cuts and their potential impact, including the loss of grants at Harvard University and the influence of external figures on NIH grant terminations. They then delve into two scientific papers: one exploring the association between endemic coronavirus infections and SARS-CoV-2 antibody responses, and another examining inherited IFNAR1 deficiency in patients with adverse reactions to live vaccines. The hosts also address listener emails, covering topics such as Patreon contributions, Wikipedia editing, podcast production, and the lab leak theory, while also sharing their "picks of the week," which include infrared contact lenses, political engagement, and the dangers of PFAS chemicals.

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This Week in Virology

Introduction to TWiV and ASV 2025 Conference Details

ASV Conference Logistics and Discussion on Science Funding Cuts

Rants on Science Funding and Introduction to Endemic Coronavirus Research

Study Design and Initial Findings on Cross-Reactive Immunity

Exploring FC-Mediated Antibody Activities and Cross-Reactivity

Further Analysis of Antibody Reactivity and Potential Vaccine Strategies

Fucosylation, Endemic Coronavirus Challenges, and Introduction to Live Vaccines

Identifying Live Vaccines and Introducing the Study on IFNAR1 Deficiency

Investigating the Impact of IFNAR1 Mutations on Immune Function

Viral Control and Discussion on Vaccine Safety and Genetic Predispositions

Listener Emails: TWiV Shirt, Wikipedia Editing, and Studio Setup

Listener Emails: Vaccine Doses, Lab Leak Theories, and the Walter Reed Biosystematics Unit

Listener Emails: Comfort from TWiV, Threats to Scientific Journals, and BSL-2+ Clarification

Picks of the Week: Infrared Vision and the Importance of Voting

Pick of the Week: PFAS Contamination and Show Conclusion

TWiV 1221: Nonsense mediated decay

This Week in Virology

00:00Introduction to TWiV and ASV 2025 Conference Details

Introduction to TWiV and ASV 2025 Conference Details

04:17ASV Conference Logistics and Discussion on Science Funding Cuts

ASV Conference Logistics and Discussion on Science Funding Cuts

14:26Rants on Science Funding and Introduction to Endemic Coronavirus Research

Rants on Science Funding and Introduction to Endemic Coronavirus Research

20:20Study Design and Initial Findings on Cross-Reactive Immunity

Study Design and Initial Findings on Cross-Reactive Immunity

28:40Exploring FC-Mediated Antibody Activities and Cross-Reactivity

Exploring FC-Mediated Antibody Activities and Cross-Reactivity

37:59Further Analysis of Antibody Reactivity and Potential Vaccine Strategies

Further Analysis of Antibody Reactivity and Potential Vaccine Strategies

45:25Fucosylation, Endemic Coronavirus Challenges, and Introduction to Live Vaccines

Fucosylation, Endemic Coronavirus Challenges, and Introduction to Live Vaccines

53:30Identifying Live Vaccines and Introducing the Study on IFNAR1 Deficiency

Identifying Live Vaccines and Introducing the Study on IFNAR1 Deficiency

1:04:47Investigating the Impact of IFNAR1 Mutations on Immune Function

Investigating the Impact of IFNAR1 Mutations on Immune Function

1:13:15Viral Control and Discussion on Vaccine Safety and Genetic Predispositions

Viral Control and Discussion on Vaccine Safety and Genetic Predispositions

1:22:17Listener Emails: TWiV Shirt, Wikipedia Editing, and Studio Setup

Listener Emails: TWiV Shirt, Wikipedia Editing, and Studio Setup

1:30:01Listener Emails: Vaccine Doses, Lab Leak Theories, and the Walter Reed Biosystematics Unit

Listener Emails: Vaccine Doses, Lab Leak Theories, and the Walter Reed Biosystematics Unit

1:38:02Listener Emails: Comfort from TWiV, Threats to Scientific Journals, and BSL-2+ Clarification

Listener Emails: Comfort from TWiV, Threats to Scientific Journals, and BSL-2+ Clarification

1:45:43Picks of the Week: Infrared Vision and the Importance of Voting

Picks of the Week: Infrared Vision and the Importance of Voting

1:52:55Pick of the Week: PFAS Contamination and Show Conclusion

Pick of the Week: PFAS Contamination and Show Conclusion